Pathogenesis of Immunosuppression after Surgical Stress

Role of oxidative stress in pathogenesis of metabolic syndrome

The metabolic syndrome (MS) recognized as a major cause of type 2 diabetes and cardiovascular diseases, has become one of the major public health challenges worldwide. The pathogenesis of the metabolic syndrome is multiple and still poorly understood. No single factor has yet been identified as an underlying causal factor. There is a growing belief, however, that obesity, specially visceral obe...

Immunosuppression after Liver Transplantation

The role of histamine receptors in restraint stress-induced immunosuppression in the rat brain

Restraint-induced stress (RS) increases histamine concentration in the brain. There is no previous report regarding the role of histamine receptors in immunomodulatory effect of RS. In the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by RS was evaluated. For this purpose male Wistar rats (200-250 g) were immunized with sheep re...

P36: Role of Brain-Derived Neurotrophic Factor in Pathogenesis and Treatment of Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a syndrome causing from a severe traumatic happening that leads to threatened death or injury. PTSD is associated with changes in limbic, hippocampal, and prefrontal cortical region function due to changes in synaptogenesis, dendritic modifying, and neurogenesis. Changes in neuron in PTSD patients result from pathophysiological disturbances in inflammato...

Surgical biology for the clinician: vascular effects of immunosuppression.

T ransplantation is the accepted treatment of end-stage organ failure. The introduction of cyclosporine (CsA) in the early 1980s greatly improved the outcome of solid organ transplantation, with an increase in 3-year survival from almost 40% to 70%. Substantial advances in the development of additional immunosuppressants have allowed transplant physicians to more specifically modulate the immun...